Cardiac adaptations to high-intensity aerobic training in premenopausal and recent postmenopausal women: The Copenhagen Women Study

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Cardiac adaptations to high-intensity aerobic training in premenopausal and recent postmenopausal women : The Copenhagen Women Study. / Egelund, Jon; Jørgensen, Peter Godsk; Mandrup, Camilla M; Fritz-Hansen, Thomas; Stallknecht, Bente; Bangsbo, Jens; Nyberg, Michael; Hellsten, Ylva.

I: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, Bind 6, Nr. 8, e005469, 2017.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Egelund, J, Jørgensen, PG, Mandrup, CM, Fritz-Hansen, T, Stallknecht, B, Bangsbo, J, Nyberg, M & Hellsten, Y 2017, 'Cardiac adaptations to high-intensity aerobic training in premenopausal and recent postmenopausal women: The Copenhagen Women Study' American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, bind 6, nr. 8, e005469. https://doi.org/10.1161/JAHA.117.005469

APA

Egelund, J., Jørgensen, P. G., Mandrup, C. M., Fritz-Hansen, T., Stallknecht, B., Bangsbo, J., ... Hellsten, Y. (2017). Cardiac adaptations to high-intensity aerobic training in premenopausal and recent postmenopausal women: The Copenhagen Women Study. American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, 6(8), [e005469]. https://doi.org/10.1161/JAHA.117.005469

Vancouver

Egelund J, Jørgensen PG, Mandrup CM, Fritz-Hansen T, Stallknecht B, Bangsbo J o.a. Cardiac adaptations to high-intensity aerobic training in premenopausal and recent postmenopausal women: The Copenhagen Women Study. American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 2017;6(8). e005469. https://doi.org/10.1161/JAHA.117.005469

Author

Egelund, Jon ; Jørgensen, Peter Godsk ; Mandrup, Camilla M ; Fritz-Hansen, Thomas ; Stallknecht, Bente ; Bangsbo, Jens ; Nyberg, Michael ; Hellsten, Ylva. / Cardiac adaptations to high-intensity aerobic training in premenopausal and recent postmenopausal women : The Copenhagen Women Study. I: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 2017 ; Bind 6, Nr. 8.

Bibtex

@article{efc86c7e02b7432e9aa601810a1eb898,
title = "Cardiac adaptations to high-intensity aerobic training in premenopausal and recent postmenopausal women: The Copenhagen Women Study",
abstract = "BACKGROUND: We examined the role of menopause on cardiac dimensions and function and assessed the efficacy of exercise training before and after menopause.METHODS AND RESULTS: Two groups of healthy premenopausal (n=36, 49.4±0.3 years) and postmenopausal (n=37, 53.5±0.5 years) women with no history of cardiovascular disease and with a mean age difference between groups of only 4 years were studied. Cardiac dimensions and systolic and diastolic function were determined by transthoracic echocardiography with tissue Doppler imaging and 2-dimensional speckle tracking. Measurements were performed at baseline and after a 12-week period of high-intensity aerobic cycle training. LV internal diastolic diameter and LV mass were similar in the 2 groups at baseline and increased by ≈2{\%} to 8{\%} (P=0.04-0.0007) with training in both groups. Left atrial end-diastolic and end-systolic volumes were similar for both groups and increased by 23{\%} to 36{\%} (P=0.0006-0.0001) with training. Systolic function assessed by mean global strain was similar in both groups at baseline and increased by ≈8{\%} (P=0.0004) with training in the postmenopausal group. LV displacement increased by ≈3{\%} (P=0.04) in the premenopausal women only. Diastolic function assessed by E/A ratio was similar at baseline and increased by ≈7{\%} (P=0.01) in the premenopausal group and 11{\%} (P=0.0001) in the postmenopausal group with training.CONCLUSIONS: These results suggest that training-induced cardiac adaptations are preserved in the early postmenopausal phase. Furthermore, the hormonal changes associated with the menopausal transition do not appear to affect cardiac dimensions and function.CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT02135575.",
keywords = "E/A ratio, Exercise training, Menopause, Transthoracic, Echocardiography, Women",
author = "Jon Egelund and J{\o}rgensen, {Peter Godsk} and Mandrup, {Camilla M} and Thomas Fritz-Hansen and Bente Stallknecht and Jens Bangsbo and Michael Nyberg and Ylva Hellsten",
note = "CURIS 2017 NEXS 237",
year = "2017",
doi = "10.1161/JAHA.117.005469",
language = "English",
volume = "6",
journal = "American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "8",

}

RIS

TY - JOUR

T1 - Cardiac adaptations to high-intensity aerobic training in premenopausal and recent postmenopausal women

T2 - The Copenhagen Women Study

AU - Egelund, Jon

AU - Jørgensen, Peter Godsk

AU - Mandrup, Camilla M

AU - Fritz-Hansen, Thomas

AU - Stallknecht, Bente

AU - Bangsbo, Jens

AU - Nyberg, Michael

AU - Hellsten, Ylva

N1 - CURIS 2017 NEXS 237

PY - 2017

Y1 - 2017

N2 - BACKGROUND: We examined the role of menopause on cardiac dimensions and function and assessed the efficacy of exercise training before and after menopause.METHODS AND RESULTS: Two groups of healthy premenopausal (n=36, 49.4±0.3 years) and postmenopausal (n=37, 53.5±0.5 years) women with no history of cardiovascular disease and with a mean age difference between groups of only 4 years were studied. Cardiac dimensions and systolic and diastolic function were determined by transthoracic echocardiography with tissue Doppler imaging and 2-dimensional speckle tracking. Measurements were performed at baseline and after a 12-week period of high-intensity aerobic cycle training. LV internal diastolic diameter and LV mass were similar in the 2 groups at baseline and increased by ≈2% to 8% (P=0.04-0.0007) with training in both groups. Left atrial end-diastolic and end-systolic volumes were similar for both groups and increased by 23% to 36% (P=0.0006-0.0001) with training. Systolic function assessed by mean global strain was similar in both groups at baseline and increased by ≈8% (P=0.0004) with training in the postmenopausal group. LV displacement increased by ≈3% (P=0.04) in the premenopausal women only. Diastolic function assessed by E/A ratio was similar at baseline and increased by ≈7% (P=0.01) in the premenopausal group and 11% (P=0.0001) in the postmenopausal group with training.CONCLUSIONS: These results suggest that training-induced cardiac adaptations are preserved in the early postmenopausal phase. Furthermore, the hormonal changes associated with the menopausal transition do not appear to affect cardiac dimensions and function.CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT02135575.

AB - BACKGROUND: We examined the role of menopause on cardiac dimensions and function and assessed the efficacy of exercise training before and after menopause.METHODS AND RESULTS: Two groups of healthy premenopausal (n=36, 49.4±0.3 years) and postmenopausal (n=37, 53.5±0.5 years) women with no history of cardiovascular disease and with a mean age difference between groups of only 4 years were studied. Cardiac dimensions and systolic and diastolic function were determined by transthoracic echocardiography with tissue Doppler imaging and 2-dimensional speckle tracking. Measurements were performed at baseline and after a 12-week period of high-intensity aerobic cycle training. LV internal diastolic diameter and LV mass were similar in the 2 groups at baseline and increased by ≈2% to 8% (P=0.04-0.0007) with training in both groups. Left atrial end-diastolic and end-systolic volumes were similar for both groups and increased by 23% to 36% (P=0.0006-0.0001) with training. Systolic function assessed by mean global strain was similar in both groups at baseline and increased by ≈8% (P=0.0004) with training in the postmenopausal group. LV displacement increased by ≈3% (P=0.04) in the premenopausal women only. Diastolic function assessed by E/A ratio was similar at baseline and increased by ≈7% (P=0.01) in the premenopausal group and 11% (P=0.0001) in the postmenopausal group with training.CONCLUSIONS: These results suggest that training-induced cardiac adaptations are preserved in the early postmenopausal phase. Furthermore, the hormonal changes associated with the menopausal transition do not appear to affect cardiac dimensions and function.CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT02135575.

KW - E/A ratio

KW - Exercise training

KW - Menopause

KW - Transthoracic

KW - Echocardiography

KW - Women

U2 - 10.1161/JAHA.117.005469

DO - 10.1161/JAHA.117.005469

M3 - Journal article

VL - 6

JO - American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease

JF - American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease

SN - 2047-9980

IS - 8

M1 - e005469

ER -

ID: 182825409