Effect of steel and teflon infusion catheters on subcutaneous adipose tissue blood flow and infusion counter pressure in humans

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Standard

Effect of steel and teflon infusion catheters on subcutaneous adipose tissue blood flow and infusion counter pressure in humans. / Højbjerre, Lise; Skov-Jensen, Camilla; Kaastrup, Peter; Pedersen, Per Elgård; Stallknecht, Bente.

I: Diabetes Technology & Therapeutics, Bind 11, Nr. 5, 2009, s. 301-6.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Højbjerre, L, Skov-Jensen, C, Kaastrup, P, Pedersen, PE & Stallknecht, B 2009, 'Effect of steel and teflon infusion catheters on subcutaneous adipose tissue blood flow and infusion counter pressure in humans', Diabetes Technology & Therapeutics, bind 11, nr. 5, s. 301-6. https://doi.org/10.1089/dia.2008.0061

APA

Højbjerre, L., Skov-Jensen, C., Kaastrup, P., Pedersen, P. E., & Stallknecht, B. (2009). Effect of steel and teflon infusion catheters on subcutaneous adipose tissue blood flow and infusion counter pressure in humans. Diabetes Technology & Therapeutics, 11(5), 301-6. https://doi.org/10.1089/dia.2008.0061

Vancouver

Højbjerre L, Skov-Jensen C, Kaastrup P, Pedersen PE, Stallknecht B. Effect of steel and teflon infusion catheters on subcutaneous adipose tissue blood flow and infusion counter pressure in humans. Diabetes Technology & Therapeutics. 2009;11(5):301-6. https://doi.org/10.1089/dia.2008.0061

Author

Højbjerre, Lise ; Skov-Jensen, Camilla ; Kaastrup, Peter ; Pedersen, Per Elgård ; Stallknecht, Bente. / Effect of steel and teflon infusion catheters on subcutaneous adipose tissue blood flow and infusion counter pressure in humans. I: Diabetes Technology & Therapeutics. 2009 ; Bind 11, Nr. 5. s. 301-6.

Bibtex

@article{019071f0366311df8ed1000ea68e967b,
title = "Effect of steel and teflon infusion catheters on subcutaneous adipose tissue blood flow and infusion counter pressure in humans",
abstract = "BACKGROUND: Subcutaneous tissue is an important target for drug deposition or infusion. A local trauma may induce alterations in local microcirculation and diffusion barriers with consequences for drug bioavailability. We examined the influence of infusion catheters' wear time on local microcirculation and infusion counter pressure. METHODS: One steel catheter and one Teflon (Dupont, Wilmington, DE) catheter were inserted in subcutaneous, abdominal adipose tissue (SCAAT) in 10 healthy, lean men. The catheters were infused with isotonic saline at a rate of 10 microL/h for 48 h. Another steel catheter and a Teflon catheter were inserted contralateral to the previous catheters after 48 h. The infusion counter pressure was measured during a basal infusion rate followed by a bolus infusion. The measurements during a basal rate infusion were repeated after the bolus infusion. Adipose tissue blood flow (ATBF) was measured in SCAAT continuously. RESULTS: A significant increase in ATBF was observed with wear time for Teflon but not for steel catheters. Mean infusion pressure during the bolus phase increased significantly from 0 to 48 h for Teflon but not for steel catheters. ATBF and infusion counter pressure was similar between Teflon and steel catheters after acute catheter implantation and after wear time of 48 h. The maximum value of pressure during the bolus phase increased with wear time of a catheter. CONCLUSIONS: ATBF and bolus mean infusion pressure increased significantly with a wear time of 48 h in Teflon but not in steel catheters. The maximal pressure required to deliver a bolus infusion increased with wear time of a catheter. A higher maximal pressure was required to deliver a bolus infusion through a Teflon than through a steel catheter. We propose that the difference in infusion counter pressure and ATBF between Teflon and steel catheters with wear time may be explained by better biocompatibility of steel than Teflon.",
author = "Lise H{\o}jbjerre and Camilla Skov-Jensen and Peter Kaastrup and Pedersen, {Per Elg{\aa}rd} and Bente Stallknecht",
note = "Keywords: Adult; Blood Flow Velocity; Body Mass Index; Calibration; Catheterization; Catheterization, Peripheral; Diabetes Mellitus; Equipment Design; Humans; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Polytetrafluoroethylene; Skinfold Thickness; Steel; Subcutaneous Fat",
year = "2009",
doi = "10.1089/dia.2008.0061",
language = "English",
volume = "11",
pages = "301--6",
journal = "Diabetes Technology & Therapeutics",
issn = "1520-9156",
publisher = "Mary AnnLiebert, Inc. Publishers",
number = "5",

}

RIS

TY - JOUR

T1 - Effect of steel and teflon infusion catheters on subcutaneous adipose tissue blood flow and infusion counter pressure in humans

AU - Højbjerre, Lise

AU - Skov-Jensen, Camilla

AU - Kaastrup, Peter

AU - Pedersen, Per Elgård

AU - Stallknecht, Bente

N1 - Keywords: Adult; Blood Flow Velocity; Body Mass Index; Calibration; Catheterization; Catheterization, Peripheral; Diabetes Mellitus; Equipment Design; Humans; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Polytetrafluoroethylene; Skinfold Thickness; Steel; Subcutaneous Fat

PY - 2009

Y1 - 2009

N2 - BACKGROUND: Subcutaneous tissue is an important target for drug deposition or infusion. A local trauma may induce alterations in local microcirculation and diffusion barriers with consequences for drug bioavailability. We examined the influence of infusion catheters' wear time on local microcirculation and infusion counter pressure. METHODS: One steel catheter and one Teflon (Dupont, Wilmington, DE) catheter were inserted in subcutaneous, abdominal adipose tissue (SCAAT) in 10 healthy, lean men. The catheters were infused with isotonic saline at a rate of 10 microL/h for 48 h. Another steel catheter and a Teflon catheter were inserted contralateral to the previous catheters after 48 h. The infusion counter pressure was measured during a basal infusion rate followed by a bolus infusion. The measurements during a basal rate infusion were repeated after the bolus infusion. Adipose tissue blood flow (ATBF) was measured in SCAAT continuously. RESULTS: A significant increase in ATBF was observed with wear time for Teflon but not for steel catheters. Mean infusion pressure during the bolus phase increased significantly from 0 to 48 h for Teflon but not for steel catheters. ATBF and infusion counter pressure was similar between Teflon and steel catheters after acute catheter implantation and after wear time of 48 h. The maximum value of pressure during the bolus phase increased with wear time of a catheter. CONCLUSIONS: ATBF and bolus mean infusion pressure increased significantly with a wear time of 48 h in Teflon but not in steel catheters. The maximal pressure required to deliver a bolus infusion increased with wear time of a catheter. A higher maximal pressure was required to deliver a bolus infusion through a Teflon than through a steel catheter. We propose that the difference in infusion counter pressure and ATBF between Teflon and steel catheters with wear time may be explained by better biocompatibility of steel than Teflon.

AB - BACKGROUND: Subcutaneous tissue is an important target for drug deposition or infusion. A local trauma may induce alterations in local microcirculation and diffusion barriers with consequences for drug bioavailability. We examined the influence of infusion catheters' wear time on local microcirculation and infusion counter pressure. METHODS: One steel catheter and one Teflon (Dupont, Wilmington, DE) catheter were inserted in subcutaneous, abdominal adipose tissue (SCAAT) in 10 healthy, lean men. The catheters were infused with isotonic saline at a rate of 10 microL/h for 48 h. Another steel catheter and a Teflon catheter were inserted contralateral to the previous catheters after 48 h. The infusion counter pressure was measured during a basal infusion rate followed by a bolus infusion. The measurements during a basal rate infusion were repeated after the bolus infusion. Adipose tissue blood flow (ATBF) was measured in SCAAT continuously. RESULTS: A significant increase in ATBF was observed with wear time for Teflon but not for steel catheters. Mean infusion pressure during the bolus phase increased significantly from 0 to 48 h for Teflon but not for steel catheters. ATBF and infusion counter pressure was similar between Teflon and steel catheters after acute catheter implantation and after wear time of 48 h. The maximum value of pressure during the bolus phase increased with wear time of a catheter. CONCLUSIONS: ATBF and bolus mean infusion pressure increased significantly with a wear time of 48 h in Teflon but not in steel catheters. The maximal pressure required to deliver a bolus infusion increased with wear time of a catheter. A higher maximal pressure was required to deliver a bolus infusion through a Teflon than through a steel catheter. We propose that the difference in infusion counter pressure and ATBF between Teflon and steel catheters with wear time may be explained by better biocompatibility of steel than Teflon.

U2 - 10.1089/dia.2008.0061

DO - 10.1089/dia.2008.0061

M3 - Journal article

C2 - 19425878

VL - 11

SP - 301

EP - 306

JO - Diabetes Technology & Therapeutics

JF - Diabetes Technology & Therapeutics

SN - 1520-9156

IS - 5

ER -

ID: 18787912