Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy

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Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy. / Enevoldsen, Lotte Hahn; Tindborg, Marie; Hovmand, Nichlas Lindegaard; Christoffersen, Christina; Ellingsgaard, Helga; Suetta, Charlotte; Stallknecht, Bente Merete; Jennum, Poul Joergen; Kjær, Andreas; Gammeltoft, Steen.

I: Sleep, Bind 41, Nr. 8, zsy092, 2018, s. 1-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Enevoldsen, LH, Tindborg, M, Hovmand, NL, Christoffersen, C, Ellingsgaard, H, Suetta, C, Stallknecht, BM, Jennum, PJ, Kjær, A & Gammeltoft, S 2018, 'Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy', Sleep, bind 41, nr. 8, zsy092, s. 1-9. https://doi.org/10.1093/sleep/zsy092

APA

Enevoldsen, L. H., Tindborg, M., Hovmand, N. L., Christoffersen, C., Ellingsgaard, H., Suetta, C., ... Gammeltoft, S. (2018). Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy. Sleep, 41(8), 1-9. [zsy092]. https://doi.org/10.1093/sleep/zsy092

Vancouver

Enevoldsen LH, Tindborg M, Hovmand NL, Christoffersen C, Ellingsgaard H, Suetta C o.a. Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy. Sleep. 2018;41(8):1-9. zsy092. https://doi.org/10.1093/sleep/zsy092

Author

Enevoldsen, Lotte Hahn ; Tindborg, Marie ; Hovmand, Nichlas Lindegaard ; Christoffersen, Christina ; Ellingsgaard, Helga ; Suetta, Charlotte ; Stallknecht, Bente Merete ; Jennum, Poul Joergen ; Kjær, Andreas ; Gammeltoft, Steen. / Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy. I: Sleep. 2018 ; Bind 41, Nr. 8. s. 1-9.

Bibtex

@article{6c864ebc716b4c26b17a95faaad39b73,
title = "Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy",
abstract = "Study objectives: To investigate the activity of brown adipose tissue (BAT) in type 1 narcolepsy patients during cold exposure using two separate scans of sympathetic and metabolic activity of BAT in order to evaluate whether orexin deficiency leads to altered non-shivering thermoregulation in narcolepsy.Methods: Seven patients with type 1 narcolepsy and seven healthy controls underwent two consecutive scans after 2 h cold exposure: 123I-meta-iodo-benzyl-guanidine (123I-MIBG) single photon emission computed tomography and 18F-2-deoxy-glucose (18F-FDG) positron emission tomography and computed tomography to visualize sympathetic innervation and metabolic activity of BAT, respectively. Plasma levels of eight hormones regulating BAT activity were measured before and after 2 h in the cold.Results: 18F-FDG-uptake and uptake of 123I-MIBG in BAT after 2 h cold exposure was observed in all individuals, but the activity of BAT was not significantly different between type 1 narcolepsy patients and healthy controls (p>0.05). Plasma levels of GLP-1 were higher in type 1 narcolepsy patients compared with controls (p<0.05), but not altered by cold adaptation in patients and controls (p>0.05). FGF21 concentrations decreased after 2 h cold exposure in both type 1 narcolepsy patients and healthy subjects (p<0.05).Conclusions: Sympathetic and metabolic activity of BAT was observed after cold exposure in patients with type 1 narcolepsy. Increased GLP-1 in narcolepsy may suggest autonomic dysfunction with metabolic changes. We conclude that BAT is functional after cold exposure in spite of the loss of orexinergic neurons in narcolepsy.",
author = "Enevoldsen, {Lotte Hahn} and Marie Tindborg and Hovmand, {Nichlas Lindegaard} and Christina Christoffersen and Helga Ellingsgaard and Charlotte Suetta and Stallknecht, {Bente Merete} and Jennum, {Poul Joergen} and Andreas Kj{\ae}r and Steen Gammeltoft",
year = "2018",
doi = "10.1093/sleep/zsy092",
language = "English",
volume = "41",
pages = "1--9",
journal = "Sleep (Online)",
issn = "0161-8105",
publisher = "Oxford University Press",
number = "8",

}

RIS

TY - JOUR

T1 - Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy

AU - Enevoldsen, Lotte Hahn

AU - Tindborg, Marie

AU - Hovmand, Nichlas Lindegaard

AU - Christoffersen, Christina

AU - Ellingsgaard, Helga

AU - Suetta, Charlotte

AU - Stallknecht, Bente Merete

AU - Jennum, Poul Joergen

AU - Kjær, Andreas

AU - Gammeltoft, Steen

PY - 2018

Y1 - 2018

N2 - Study objectives: To investigate the activity of brown adipose tissue (BAT) in type 1 narcolepsy patients during cold exposure using two separate scans of sympathetic and metabolic activity of BAT in order to evaluate whether orexin deficiency leads to altered non-shivering thermoregulation in narcolepsy.Methods: Seven patients with type 1 narcolepsy and seven healthy controls underwent two consecutive scans after 2 h cold exposure: 123I-meta-iodo-benzyl-guanidine (123I-MIBG) single photon emission computed tomography and 18F-2-deoxy-glucose (18F-FDG) positron emission tomography and computed tomography to visualize sympathetic innervation and metabolic activity of BAT, respectively. Plasma levels of eight hormones regulating BAT activity were measured before and after 2 h in the cold.Results: 18F-FDG-uptake and uptake of 123I-MIBG in BAT after 2 h cold exposure was observed in all individuals, but the activity of BAT was not significantly different between type 1 narcolepsy patients and healthy controls (p>0.05). Plasma levels of GLP-1 were higher in type 1 narcolepsy patients compared with controls (p<0.05), but not altered by cold adaptation in patients and controls (p>0.05). FGF21 concentrations decreased after 2 h cold exposure in both type 1 narcolepsy patients and healthy subjects (p<0.05).Conclusions: Sympathetic and metabolic activity of BAT was observed after cold exposure in patients with type 1 narcolepsy. Increased GLP-1 in narcolepsy may suggest autonomic dysfunction with metabolic changes. We conclude that BAT is functional after cold exposure in spite of the loss of orexinergic neurons in narcolepsy.

AB - Study objectives: To investigate the activity of brown adipose tissue (BAT) in type 1 narcolepsy patients during cold exposure using two separate scans of sympathetic and metabolic activity of BAT in order to evaluate whether orexin deficiency leads to altered non-shivering thermoregulation in narcolepsy.Methods: Seven patients with type 1 narcolepsy and seven healthy controls underwent two consecutive scans after 2 h cold exposure: 123I-meta-iodo-benzyl-guanidine (123I-MIBG) single photon emission computed tomography and 18F-2-deoxy-glucose (18F-FDG) positron emission tomography and computed tomography to visualize sympathetic innervation and metabolic activity of BAT, respectively. Plasma levels of eight hormones regulating BAT activity were measured before and after 2 h in the cold.Results: 18F-FDG-uptake and uptake of 123I-MIBG in BAT after 2 h cold exposure was observed in all individuals, but the activity of BAT was not significantly different between type 1 narcolepsy patients and healthy controls (p>0.05). Plasma levels of GLP-1 were higher in type 1 narcolepsy patients compared with controls (p<0.05), but not altered by cold adaptation in patients and controls (p>0.05). FGF21 concentrations decreased after 2 h cold exposure in both type 1 narcolepsy patients and healthy subjects (p<0.05).Conclusions: Sympathetic and metabolic activity of BAT was observed after cold exposure in patients with type 1 narcolepsy. Increased GLP-1 in narcolepsy may suggest autonomic dysfunction with metabolic changes. We conclude that BAT is functional after cold exposure in spite of the loss of orexinergic neurons in narcolepsy.

U2 - 10.1093/sleep/zsy092

DO - 10.1093/sleep/zsy092

M3 - Journal article

VL - 41

SP - 1

EP - 9

JO - Sleep (Online)

JF - Sleep (Online)

SN - 0161-8105

IS - 8

M1 - zsy092

ER -

ID: 198408094