PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training

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Martin Baeek Blond, Theresia Maria Schnurr, Mads Rasenkilde, Jonas Sailing Quist, Anne Sofie Gram, Michala Holm Reichkendler, Pernille Landrock Auerbach, Pernille Nordby, Lene Theil Skovgaard, Rasmus Ribel-Madsen, Johann Marie Justesen, Tuomas Oskari Kilpelainen, Thorkil Ploug, Bente Merete Stallknecht, Torben Hansen

The Ala allele of PPARG Pro12Ala (rs1801282) is associated with greater improvements to the glucose metabolism in exercise studies, but whether this extends to peripheral insulin sensitivity is unknown. Our objective was to investigate the effect of PPARG Pro12Ala on exercise-induced changes in peripheral insulin sensitivity. A total of 124 (91 Pro homozygotes and 33 Ala carriers) previously physically inactive healthy young men and women with overweight or class 1 obesity who completed a 12 wk aerobic exercise intervention were included in the analysis. All participants underwent a hyperinsulinemic euglycemic clamp before and after the 12 wk intervention. The prescribed exercise frequency was 5-7 days/wk, and the exercise energy expenditure was 2,100 4,200 kcal/wk for men and 1,600 kcal/wk for women. Insulin sensitivity improved significantly in both genotype groups. However, Ala carriers had a 1.13-fold (95% confidence interval 1.01; 1.26, P = 0.032) greater improvement in insulin sensitivity from baseline compared with Pro homozygotes. Our data support that PPARG Pro12Ala modifies the effect of aerobic exercise on peripheral insulin sensitivity.
OriginalsprogEngelsk
TidsskriftPhysiological Genomics
Vol/bind51
Udgave nummer6
Sider (fra-til)254-260
ISSN1094-8341
DOI
StatusUdgivet - 2019

ID: 223871442